Short report: interferon-alpha decreases 14C-aminopyrine breath test values in patients with chronic hepatitis C
(1994) Alimentary Pharmacology and Therapeutics — Vol. 8, n° 3, p. 353-355 (1994)
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- OBJECTIVE: To investigate the effect of interferon-alpha on cytochrome P-450 dependent microsomal function. METHODS: The 14C-aminopyrine breath test was performed before, during and after a standard dose of interferon-alpha (3,000,000 units three times per week) was administered for at least six months (nine patients with chronic hepatitis C). RESULTS: Mean aminopyrine breath test values obtained during therapy were significantly lower than either pre- or post-treatment, the degree of reduction varying widely between individuals. Pre- and post-treatment aminopyrine breath test values did not differ significantly. CONCLUSION: Interferon therapy is associated with a significant and transient inhibition of cytochrome P-450 activity, which should be taken into account when prescribing concurrent therapy with drugs metabolized by this pathway.
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Horsmans, Y., Brenard, R., & Geubel, A. (1994). Short report: interferon-alpha decreases 14C-aminopyrine breath test values in patients with chronic hepatitis C. Alimentary Pharmacology and Therapeutics, 8(3), 353-355. https://doi.org/10.1111/j.1365-2036.1994.tb00301.x (Original work published 1994)