L'ictère est-il une cause d'erreur dans l'interprétation du CA 19-9 sérique?
(1989) Acta Gastro-Enterologica Belgica (Multilingual Edition) — Vol. 52, n° 1-2, p. 17-22 (1989)
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- Serum CA 19-9 has been proposed as a tumour marker for pancreatic cancer (PC). However, false positive results are seen in sera of patients with benign jaundice. The CA 19-9 assay was performed by a solid state radioimmunoassay in 86 icteric patients (total bilirubin greater than 2 mg/dl). 24/86 had PC (12 men, 12 women, mean age 74 years) and 62/86 had benign jaundice (29 men, 33 women, mean age 56 years; cirrhosis: n = 20, angiocholitis: n = 21, hepatitis: n = 21). At a cut-off level of 60 U./ml, for detecting icteric PC, sensitivity was 83%, and specificity was 79%. At 120 U./ml, sensitivity was 79%, but specificity was increased to 92%. We conclude that 21% of patients with benign jaundice had a CA 19-9 level greater than 60 U./ml, and using a CA 19-9 level of 120 U./ml, the specificity of the test to detect icteric PC was increased, with little decrease in the sensitivity.
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Nakad, A., Colombel, J. F., Geubel, A., Cerulus, G., Farchakh, E., Degrez, T., Janssen, J., Cortot, A., Paris, J., & Dive, C. (1989). L’ictère est-il une cause d’erreur dans l’interprétation du CA 19-9 sérique? Acta Gastro-Enterologica Belgica (Multilingual Edition), 52(1-2), 17-22. https://hdl.handle.net/2078.5/50347 (Original work published 1989)