Postallograft aleukemic mast cell leukemia, with macrophagic activation syndrome
(2022) EJHaem — Vol. 3, n° 4, p. 1435-1437 (2022)
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- (en) A 60‐year‐old male suffering from hypertension and a treated myelodysplastic syndrome (MDS‐EB2) by an allograft 3 years before the current presentation was presented with a deteriorating general condition and asthenia. A blood work‐up was done where hypereosinophilia (24 × 103/μl) was incidentally found, hardly attributable to a postallogeneic peripheral blood stem cell transplantation [2].The patient was then referred to our hematology department for further investigation. Upon admission, a myelogram revealed 7% of mastocytes, often in aggregates, some showing atypical forms (hypogranulation, spindle‐shape, and hypersegmentation of nucleus), and 51% of eosinophilic lineage. Flow cytometry (FC) showed 7% of mast cells with CD2 and CD25 aberrant expression. [...]
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Citations
Hamdash, S., Deckers, C., Chapelle, V., Vanderdonck, M., Saussoy, P., & Rousseaux, M. (2022). Postallograft aleukemic mast cell leukemia, with macrophagic activation syndrome. EJHaem, 3(4), 1435-1437. https://doi.org/10.1002/jha2.431 (Original work published 2022)