The question of threshold doses for radiation damage: malformations induced by radiation exposure of unicellular or multicellular preimplantation stages of the mouse.
(1994) Radiation and Environmental Biophysics — Vol. 33, n° 1, p. 63-68 (1994)
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Details
- Authors
- Abstract
- Mouse embryos of the one-cell stage or the 32- to 64-cell stage were exposed to various X-ray doses (one-cell stage: 0.25-2 Gy; 32- to 64-cell stage: 1-3 Gy). It turned out that the shape of the dose-response curves is statistically compatible with the assumption derived from biological considerations that there is no threshold for radiation-induced malformations in the case of the exposure of one-cell embryos, whereas there is a threshold dose (close to 1 Gy) in the case of the exposure of 32- to 64-cell embryos.
- Affiliations
Universitätsklinikum Essen
Citations
Müller, W. U., Streffer, C., & Pampfer, S. (1994). The question of threshold doses for radiation damage: malformations induced by radiation exposure of unicellular or multicellular preimplantation stages of the mouse. Radiation and Environmental Biophysics, 33(1), 63-68. https://doi.org/10.1007/BF01255274 (Original work published 1994)