Historical Perspectives in the Development of Antiviral Agents Against Poxviruses
(2010) Viruses — Vol. 2, n° 6, p. 1322-1339 (2010)
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- Abstract
- The poxvirus vaccinia virus (VV) served as the model virus for which the first antivirals, the thiosemicarbazones, were identified. This dates back to 1950; and, although there is at present no single antiviral drug specifically licensed for the chemotherapy or - prophylaxis of poxvirus infections, numerous candidate compounds have been described over the past 50 years. These compounds include interferon and inducers thereof (i.e., polyacrylic acid), 5-substituted 2'-deoxyuridines (i.e., idoxuridine), IMP dehydrogenase inhibitors, S-adenosylhomocysteine hydrolase inhibitors, acyclic nucleoside phosphonates (such as cidofovir) and alkoxyalkyl prodrugs thereof (such as CMX001), viral egress inhibitors (such as tecovirimat), and cellular kinase inhibitors (such as imatinib).
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De Clercq, E. (2010). Historical Perspectives in the Development of Antiviral Agents Against Poxviruses. Viruses, 2(6), 1322-1339. https://doi.org/10.3390/v2061322 (Original work published 2010)