Oxidation of low density lipoproteins by myeloperoxidase at the surface of endothelial cells: an additional mechanism to subendothelium oxidation
(2004) Biochemical and Biophysical Research Communications — Vol. 325, n° 2, p. 434-438 (2004)
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- Abstract
- The present paradigm of atherogenesis proposes that low density lipoproteins (LDL) are trapped in subendothelial space of the vascular wall where they are oxidized. Myeloperoxidase (MPO) plays a key role in oxidative damage. We propose that LDL oxidation by myeloperoxidase (Mox-LDL) could occur at the surface of the endothelial cells and not restricted to the subendothelial space. The triad constituted by endothelial cells, circulating LDL and MPO in close interaction, constitutes a synergic mechanism for the genesis of Mox-LDL. (C) 2004 Elsevier Inc. All rights reserved.
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Boudjeltia, K., Moguilevsky, N., Legssyer, I., Babar, S., Guillaume, M., Delrée, P., Vanhaeverbeek, M., Brohee, D., Ducobu, J., & Remacle, C. (2004). Oxidation of low density lipoproteins by myeloperoxidase at the surface of endothelial cells: an additional mechanism to subendothelium oxidation. Biochemical and Biophysical Research Communications, 325(2), 434-438. https://doi.org/10.1016/j.bbrc.2004.10.049 (Original work published 2004)