Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms.

Vinetti, Marco;Haufroid, Vincent;Capron, Arnaud;Classen, Jean-François;Hantson, Philippe;et.al.
(2011) Clinical Toxicology — Vol. 49, n° 9, p. 865-869 (2011)

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Abstract
Venlafaxine (VEN) is a serotonin-norepinephrine-dopamine reuptake inhibitor that causes usually a mild cardiotoxicity when ingested in overdose. We report a patient who developed acute heart failure following overdose. As the toxicokinetic data suggested a prolonged metabolism, genetic polymorphisms for cytochrome P450 isoenzymes CYP2D6 and CYP2C19 were also investigated.
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Vinetti, M., Haufroid, V., Capron, A., Classen, J.-F., Marchandise, S., & Hantson, P. (2011). Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms. Clinical Toxicology, 49(9), 865-869. https://doi.org/10.3109/15563650.2011.626421 (Original work published 2011)